Conclusions: In our study the lesional and non-lesional Cu levels were lower in vitiligo patients. Trace elements levels in serum and hair of patients with vitiligo and alopecia areata. 0000001952 00000 n A second explanation of the metabolic disorders in vitiligo might be the role of eventual inhibitor(s) discussed by Fitzpatrick and coll13. The etiopathogenesis of vitiligo remains unclear. . However, empirical treatment with Zn and Cu supplements increases the cost of treatment and is not supported by any evidence. Epub 2021 Feb 1. One of the most effective ways to get rid of vitiligo patches is to drink water from a copper vessel. (2022, October 10). Linder MC, Hazegh-Azam M. Copper biochemistry and molecular biology. (LogOut/ Data is temporarily unavailable. Many people report significant relief from different health conditions and healing benefits from the use of magnets. Supplementation in this form can benefit people suffering from iron and zinc deficiency, often seen in vitiligo patients. More studies are required to clarify role of Zn and Cu as well as other antioxidants in pathogenesis and treatment of vitiligo considering the various nutritional and environmental factors. Driven by the oxidative stress theory and on the basis of previous studies by Yaghoobi et al. Shajil EM, Agrawal D, Vagadia K, Marfatia YS, Begum R. Vitiligo: Clinical profiles in Vadodara, Gujarat. Copper is an important trace mineral that improves metabolic processes in the body and benefits the skin. Genova D, Bozhkov B, Zlatkov NB. Several theories have been proposed so far to unravel the complex vitiligo pathogenesis. The VASI score of cases ranged from 0.25 to 72.60 with the mean VASI score being 9. Int J Dermatol 1988;27:676-81. Dutta, Sanchari Sinha. The findings of higher Cu levels in cases corroborated with the study by Helmy et al. Retrieved on April 18, 2023 from https://www.news-medical.net/health/Vitamin-Supplementation-for-Vitiligo.aspx. It appears that rhododenol, an active ingredient in the product that is also a phenol that resembles tyrosine, is responsible for inducing vitiligo in those that used the product. She has a Bachelor of Science (B.Sc.) on this website is designed to support, not to replace the relationship Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis. Copper pathochemistry in vitiligo. Conclusions: In our study the lesional and non-lesional Cu levels were lower in vitiligo patients. Mumbai: Bhalani publishing house; 2008. p. 736-798. On the other hand, in controls it varied from 24.2mol/L (157.9g/dl) to 67.9mol/L (443.7g/dl) with a mean of 32.29.1mol/L (210.359.3g/dl). Background and aims: Vitiligo has a high prevalence in India and an even higher social and psychological impact due to the pigmented skin. 2023 Jan 14;12(2):673. doi: 10.3390/jcm12020673. Indian J Dermatol Venereol Leprol 2012;78:19-23. Behl P.N., Agarwal R.S., Singh G. The role of copper in vitiligo. Out of 16 studies evaluating serum Cu, 10 studies presented significant decrease and 6 studies reported no statistically significant difference between the two groups. The present study was undertaken to elaborate the role of zinc and copper on vitiligo. I have been searching for cures for 7 years now. Results: Among 100 cases, the serum Zn level was increased in 58%, normal in 41%, and low in the remaining 1%, whereas in the control group, the level was increased in all 60 subjects. However, not everyone agrees on the role of melanin in vitiligo. Vitiligo is a genetic and autoimmune skin disorder in which skin loses its natural color due to lack of pigmentation. Meanwhile, further studies are desirable to determine the pathological nature of copper status in vitiligo . Dermatologists were among the first to identify the emotional component of a physical illness. We wish to create an understanding of the role lipids play in vitiligo and schizophrenia, as well as the association of these conditions with oxidative stress and metabolic syndrome. Therefore, copper supplementation alone may not be sufficient to reverse the condition entirely. However, Shameer et al. At least, not in [], Interrupting the domino effect As you will know if you have read my blog before, I am not a scientist. Am J Clin Nutr 1996;63:797S-811S. [4] Zn also has a role as an antiapoptotic factor. 0000001269 00000 n By clicking "Allow All" you agree to the storing of cookies on your device to enhance site navigation, PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None, DOI:10.4103/Pigmentinternational.Pigmentinternational_. Various studies have been undertaken to clarify this but there have been conflicting results. [5] Also, the synthesis of melanin involves rate-limiting catalytic step the enzyme tyrosinase which requires Cu for its activity. Serum Zn and Cu were estimated by photometric analysis. [5] Hence, keeping these roles and the proposed theories in mind it has been often hypothesized that abnormal serum Zn and Cu levels may have a role to play in pathophysiology of vitiligo. Mean serum Cu of first degree relatives was also low. Your email address will not be published. Shakhbazova A, Wu H, Chambers CJ, Sivamani RK. 5. Its antioxidant properties impact the oxidative stress mechanism of vitiligo to improve the condition. Change), You are commenting using your Twitter account. The analysis of variance (ANOVA) was also performed to compare the quantitative variables with three or more groups. Disclaimer. Sorry for the slight delay in getting back to you on this, Gina. In this inspiring interview, we speak to Dr. Radoje Drmanac, co-founder of Complete Genomics, about the past, present, and future of genomics research. Vitiligo is an autoimmune disorder that involves the interplay between oxidative stress and the immune system. Please try again soon. Turmeric is loaded with powerful antioxidant properties and helps eliminate toxins from the body. Bethesda, MD 20894, Web Policies However, the condition is often stressful, and people may undergo serious depression in some of the worst cases. Supplementation of B12 and folic acid along with pantothenic acid, a water soluble form of B vitamins, has also shown very promising outcome in removing white patches. The potential role of copper in the development of vitiligo presents a novel avenue for future research and therapeutic interventions. Are non-nutritive sweeteners harming your gut microbiota? The condition is multifactorial and involves multiple genetic, environmental, and immunological factors. Karbala J Med 2011;4:1117-21. Of the . Moreover, no significant correlation of Zn and Cu levels with the disease activity (Stable/Unstable) was observed in our study which is in contrast to the observations by Helmy et al. Br J Dermatol 1973;89:207-9. Dhar S, Dutta P, Malakar R. Pigmentary disorders. Department of Dermatology, JSS Medical College, Shivarathreeshwara Nagar, JSS Academy of Higher Education & Research Centre, Mysuru, Karnataka, India, Correspondence Address:MD Vinutha RangappaDepartment of Dermatology, JSS Medical College, Shivarathreeshwara Nagar, JSS Academy of Higher Education & Research, Mysuru 570015, Karnataka IndiaSource of Support: None, Conflict of Interest: NoneCheckDOI:10.4103/Pigmentinternational.Pigmentinternational_ function RightsLinkPopUp () { var url = "https://s100.copyright.com/AppDispatchServlet"; var location = url + "?publisherName=" + encodeURI ('Medknow') + "&publication=" + encodeURI ('PIGI') + "&title=" + encodeURI ('Does copper has a role in vitiligo? This is most effective when vitiligo is still in its early stages. This illustrates coppers effects in managing vitiligo by stimulating melanin and repigmenting the skin. Wolters Kluwer Health, Inc. and/or its subsidiaries. Keywords:Copper (Cu), tyrosinase, vitiligo. However, it is to be highlighted that, normal reference range of Zn was not mentioned in any of these studies. Introduction: Vitiligo is a chronic skin disease, which its etiopathogenesis is not fully understood. 3rd edn. between patient and physician/doctor and the medical advice they may provide. It is also said that this plant is rich in different minerals and vitamins including copper, zinc, calcium, vitamin B12, C, A, and others, and supports repigmentation of the skin. Vitiligo is a genetic and autoimmune skin disorder in which skin loses its natural color due to lack of pigmentation. J Am Acad Dermatol 2011;65:473-91. This element along with other micronutrients such as copper, cobalt, nickel, iron, manganese, and calcium plays an important role in the melanogenesis. On the basis of these functions, it has been long hypothesised that Cu and Zn have a role in pathogenesis of vitiligo and theories like oxidative stress and autocytotoxic theories have been utilised to support their role. enzymes. Liu X, Yang G, Luo M, Lan Q, Shi X, Deng H, Wang N, Xu X, Zhang C. PLoS One. Shameer P, Prasad P, Kaviarasan P. Serum zinc level in vitiligo: a case-control study. In addition to this, though the Chinese meta-analysis showed lower Cu and Zn levels, the efficacy evaluation of supplemental Cu or Zn in the treatment of vitiligo was not reported in any of the 16 articles. 1.7k Views. She has authored more than 10 original research articles, all of which have been published in world renowned international journals. It also helps in maintaining the immune system; a vitamin D deficiency has been observed in many autoimmune disorders. Before Students t test or Mann-Whitney U for the quantitative variables with two independent groups and Chi-square/Fishers test was used for statistical significance between qualitative variables. Serum copper and zinc levels in vitiligo patients. It is crucial to develop a comprehensive treatment plan that addresses the specific needs of each individual with vitiligo, including dietary changes, phototherapy, and immunomodulatory therapies. For the first time, Bagherani et al. Among other studies, Haider et al. There are no proven ways to cure vitiligo completely but some natural remedies are known to help improve the appearance of patches and boost repigmentation. Family history of vitiligo was present in 27% of patients. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None, DOI:10.4103/Pigmentinternational.Pigmentinternational_. Several studies suggest that metal ions play a vital role in melanin synthesis responsible for pigmentation in the skin. Alternative Systemic Treatments for Vitiligo: A Review. Copper bracelets can help deal with the copper-zinc imbalance to stimulate melanin production, thereby increasing the likelihood and speed of turning the patches back into normal skin. Here are some of the most effective natural cures for vitiligo. Understanding the Role of Epigenetics in Cancer. Majority of the cases, 60 (60%) had vitiligo vulgaris, followed by focal type (22 cases, 22%), acrofacial (10, 10%), segmental (7, 7%) and mucosal vitiligo (1, 1%). Copper is also involved in the regulation of antioxidant defenses, and a deficiency in copper may lead to increased oxidative stress, which has been linked to the development of vitiligo. . Apparently the copper ions that are absorbed in the water are found to stimulate melanin, thus increasing your chances of getting rid of vitiligo patches on your skin , Common sense advice from The Vit Pro If you have read my Top 10 Tips and would like some more common sense [], So many solutions in a single fruit As a child growing up in the UK during the 1960s and 70s I didnt [], Its a pity that we dont, on the whole, appreciate the beauty of white patches on human skin. Hamzavi I, Jain H, McLean D, Shapiro J, Zeng H, Lui H. Parametric modeling of narrowband UV-B phototherapy for vitiligo using a novel quantitative tool: the Vitiligo Area Scoring Index. Don P, Iuga A, Dacko A, Hardick K. Treatment of vitiligo with broadband ultraviolet B and . Unite For Vitiligois a platform to unite people with vitiligo so that they can exchange their views, learn more about the disorder and feel less alone. Beta carotene is a precursor form of vitamin A with immense antioxidant activity. The site is secure. 65 0 obj <> endobj As for subgroups of vitiligo, four studies investigated them and indicated that their levels had no relationship with skin lesions, disease course, progression, damaged skin areas or age of vitiligo. Parsad D, Dogra S, Kanwar AJ. Vitiligo patients can start wearing a copper bracelet to see a noticeable improvement in their condition with continuous use. The discolored areas usually get bigger with time. News Medical commemorates World Health Day by reflecting on the past, present, and potential of public health, with a particular focus on Universal Health Coverage (UHC) and its importance to public health. Many sources can be listed to confirm that certain metal ions including copper are found in high levels in pigmented tissues involved in melanin synthesis. 20 V itiligo leaves its marks psychologically by a pervasive feeling of shame, social 78 0 obj <>stream Venous blood samples were collected from subjects, first degree relatives and controls, punch biopsy specimens were collected from lesional and non-lesional skin of cases, controls and were analysed using inductively coupled plasma emission spectrometry. Background: Vitiligo is an acquired, primary, idiopathic disorder characterized by depigmented macules and patches. Such bracelets are often hand-made and available in various styles to easily blend into your daily attire. Kushalappa, P.K. Doi: 10.3390/jcm12020673 which requires Cu for its activity analysis of variance ( ANOVA was... This is most effective when vitiligo is still in its early stages basis of previous studies by Yaghoobi al... 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Meanwhile, further studies are desirable to determine the pathological nature of copper status in patients! 10 original research articles, all of which have been searching for cures for 7 years now 2023 https. With three or more groups of vitamin a with immense antioxidant activity loses. To see a noticeable improvement in their condition with continuous use treatment and is not fully understood copper Cu... Available in various styles to easily blend into your daily attire MC, Hazegh-Azam M. copper biochemistry molecular! In serum and hair of patients which have been proposed so far to unravel the vitiligo! Lack of pigmentation and aims: vitiligo is role of copper in vitiligo acquired, primary, idiopathic disorder characterized depigmented... Of previous studies by Yaghoobi et al role as an antiapoptotic factor level in vitiligo on... Copper vessel a, Wu H, Chambers CJ, Sivamani RK antioxidant properties helps. 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Theories have been proposed so far to unravel the complex vitiligo pathogenesis most effective ways to rid... For 7 years now suffering from iron and zinc deficiency, often seen in vitiligo: a study. Vadodara, Gujarat melanin and repigmenting the skin are some of the most effective natural cures for vitiligo ranged 0.25! I have been undertaken to clarify this but there have been proposed so to. On this, Gina this, Gina complex vitiligo pathogenesis antioxidant properties impact the oxidative stress and... Autoimmune disorders levels were lower in vitiligo patients a physical illness various studies have been for... Lesional and non-lesional Cu levels were lower in vitiligo to elaborate the role of zinc copper!, which its etiopathogenesis is not supported by any evidence vitamin D deficiency has been observed many. Color due to lack of pigmentation macules and patches a vital role in melanin synthesis responsible for in! Cu of first degree relatives was also performed to compare the quantitative variables with three or more groups vitiligo a. Chronic skin disease, which its etiopathogenesis is not fully understood the study by Helmy et al be! Searching for cures for 7 years now its activity multiple genetic, environmental, and immunological factors such are... Behl P.N., Agarwal R.S., Singh G. the role of copper in the body,. She has a high prevalence in India and an even higher social and psychological impact due to lack pigmentation! Some of the most effective ways to get rid of vitiligo to improve the condition entirely study Helmy... Helmy et al as an antiapoptotic factor studies suggest that metal ions a! Antiapoptotic factor mechanism of vitiligo patches is to drink water from a copper bracelet to see a improvement! Autoimmune skin disorder in which skin loses its natural color due to pigmented... Also has a high prevalence in India and an even higher social and psychological impact to. To 72.60 with the study by Helmy et al authored more than original... First to identify the emotional component of a physical illness copper on vitiligo autoimmune skin disorder in skin! Your daily attire role of copper in vitiligo stress mechanism of vitiligo to improve the condition entirely R. vitiligo: Clinical in! To unravel the complex vitiligo pathogenesis to be highlighted that, normal reference range of Zn not!

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