Chan, F. L., Choi, H. L., Chen, Z. Y., Chan, P. S., and Huang, Y. Common substitutions for Baikal skullcap in Chinese medicine include related plants whose scientific names are Scutellaria viscidula, Scutellaria amonea, and Scutellaria ikoninikovii. View abstract. View abstract. Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others. Planta Med 1995;61(2):150-153. View abstract. Immunopharmacology 2000;49:295-306. Go, W. J., Ryu, J. H., Qiang, F., and Han, H. K. Evaluation of the flavonoid oroxylin A as an inhibitor of P-glycoprotein-mediated cellular efflux. Dong R, Li L, Gao H, et al. Cancer Chemother.Pharmacol 2011;67(5):1063-1072. Pharmacotherapy 2010;30(7):750, 258e-750, 262e. Mu, X., He, G., Cheng, Y., Li, X., Xu, B., and Du, G. Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Planta Med 2000;66(8):694-698. J Ethnopharmacol. Phytother.Res 2007;21(9):900-903. Alcohol can cause sleepiness and drowsiness. This traditional Chinese medicine has a long history and was used for a healthy heart and mind. Small studies in humans suggest that S. barbata may benefit patients with advanced breast cancer. J Med Food 2014;17(6):707-13. Drug Metab Dispos 2005;33:537-46. Huang, R. L., Chen, C. C., Huang, H. L., Chang, C. G., Chen, C. F., Chang, C., and Hsieh, M. T. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. Baikal skullcap might also cause sleepiness and drowsiness. Avoid handling which leads to dust formation. Am J Chin Med 2011;39(4):693-704. Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., and Zhang, D. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. 11-1-2009;284(2):198-207. Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. New York, NY: CRC Press LLC. Planta Med 2001;67(5):396-399. 2021 Mar;10(3):2979-2989. In animal models, attenuation of asthma was attributed to reduced airway injury and restored mitochondrial function(19). Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. Z. Extraction of polysaccharides from herbal, Anti-angiogenic effect of the total flavonoids in. J Chromatogr.A 3-19-2010;1217(12):1875-1881. View abstract. Chinese skullcap can decrease the blood level of several drugs used to lower cholesterol levels. View abstract. In Vivo 2004;18(4):497-503. In human colon cancer cells, S. barbata induces apoptosis and inhibits cell proliferation and angiogenesis via Akt and p53 modulation, Bax/Bcl-2 upregulation, decreased cyclin D1/CDK4 expression, G1/S cell cycle arrest, VEGF-A inhibition, and increased p21 expression(19)(20)(26)(27). Udintsev, S. N., Razina, T. G., and Iaremenko, K. V. [The antitumor effect of Baikal skullcap]. Kowalczyk, E., Krzesinski, P., Kura, M., Niedworok, J., Kowalski, J., and Blaszczyk, J. Z., Wang, Y., and Liu, B. Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. View abstract. View abstract. Health Benefits An intravenous preparation that includes Baikal skullcap, forsythia, and honeysuckle has been used under medical supervision with apparent safety in children for up to 7 days. Herbal hepatoxicity from Chinese skullcap: A case report. Wang, J., Yu, Y., Hashimoto, F., Sakata, Y., Fujii, M., and Hou, D. X. Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells. Baicalin from the extract of Scutellaria baicalensis affects the innate immunity and apoptosis in leukocytes of children with acute lymphocytic leukemia. Z., Bai, L., Chen, D. G., Xu, Q. T., and Southerland, W. M. Computational investigation of the anti-HIV activity of Chinese medicinal formula Three-Huang Powder. View abstract. View abstract. Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy. View abstract. View abstract. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. Preclinical studies of S. barbata have focused mostly on colon, lung, and liver cancer models. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, indomethacin (Indocin), ticlopidine (Ticlid), warfarin (Coumadin), and others. Vopr.Onkol. Taking Baikal skullcap along with metformin (Glucophage) might increase the effectiveness of metformin (Glucophage) for lowering blood sugar. Altavilla D, Squadrito F, Bitto A, et al. Wang R.T, Zhang J.X, and Dong Y.J. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Jianjun, J. and Huiru, D. Preparation of high-purity baicalein from Scutellaria baicalensis Georgi. Talk with your healthcare provider before using this product if you are taking lithium. Scutellaria Macrantha , Scutellaria Baicalensis, Family: Lamiaceae. Baikal skullcap might decrease how quickly the liver breaks down some medications. Baikal skullcap might increase how quickly the liver breaks down some medications. Chinese skullcap (Scutellaria baicalensis Georgi) inhibits inflammation and proliferation on benign prostatic hyperplasia in rats. View abstract. Int Immunopharmacol 2014;23(2):558-67. New York, NY: CRC Press LLC. Porterfield, H. UsToo PC-SPES surveys: review of studies and update of previous survey results. View abstract. 9-7-2009;125(2):286-290. If you have any condition that might be made worse by exposure to estrogen, don't use Baikal. Z., Wang, Y., and Liu, B. Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. Leuk.Res 2007;31(4):523-530. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. View abstract. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. Am J Chin Med 2006;34(2):245-261. Li, T., Li, N., Guo, Q., Ji, H., Zhao, D., Xie, S., Li, X., Qiu, Z., Han, D., Chen, X., and You, Q. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. Many lab tests have shown that this time is a herb that also results in blood thinning which can cause an increased risk of bleeding and bruising. J Altern Complement Med 2002;8(5):567-572. Visit the FDA MedWatch website or call 1-800-FDA-1088. J Med Food 2007;10:442-51. View abstract. Kim, D. S., Son, E. J., Kim, M., Heo, Y. M., Nam, J. Huang, R. L., Chen, C. C., Huang, H. L., Chang, C. G., Chen, C. F., Chang, C., and Hsieh, M. T. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. J AOAC Int 2009;92(3):785-788. December 19, 2017. Blood 2-15-2008;111(4):2354-2363. OTHER NAME(S): Baicalein, Baikal Scullcap, Baikal Skullcap Root. Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of benzo[a]pyrene 7,8-dihydrodiol and benzo[a]pyrene 7,8-dihydrodiol-9,10-epoxide. Users of this Web site should not rely on information provided on this Web site for their own health problems. View abstract. Ai.Zheng. Taking Baikal skullcap along with medications that also slow clotting might increase the chances of bruising and bleeding. Ha, K. T., Kim, J. K., Kang, S. K., Kim, D. W., Lee, Y. C., Kim, H. M., and Kim, C. H. Inhibitory effect of Sihoga-Yonggol-Moryo-Tang on matrix metalloproteinase-2 and -9 activities and invasiveness potential of hepatocellular carcinoma. View abstract. View abstract. Kaplya, O. View abstract. Studies in humans are quite limited. View abstract. A traditional Planta Med 1997;63(2):141-145. Hua Xi.Kou Qiang.Yi.Xue.Za Zhi 2006;24(2):131-134. Pneumonitis induced by ou-gon (scullcap). Anticancer Res 2007;27(1A):117-125. 2010;17(10):760-770. The root has been used in Chinese medicine for psychiatric disorders. Toxicology 3-4-2009;257(1-2):80-85. Whether co-administration of garlic has negative influence on Scutellaria baicalensis Georgi in treating models rats with pelvic inflammation? We currently have no information for BAIKAL SKULLCAP overview. View abstract. Available at: https://www.fda.gov/food/alerts-advisories-safety-information/fda-alerts-consumers-about-potentially-life-threatening-health-problems-linked-limbrel. WebDescription:scutellaria baicalensis root extract is an extract of the roots of the scutellaria baicalensis, lamiaceae. Martin, J. and Dusek, J. Flavonoid accumulation in Scutellaria baicalensis Georgii in vitro cultures upon treatment with sodium cinnamate. 12-10-2008;8(12):1652-1657. Homma, M., Oka, K., Taniguchi, C., Niitsuma, T., and Hayashi, T. Systematic analysis of post-administrative saiboku-to urine by liquid chromatography to determine pharmacokinetics of traditional Chinese medicine. Chen, L. G., Hung, L. Y., Tsai, K. W., Pan, Y. S., Tsai, Y. D., Li, Y. View abstract. Hao, H., Aixia, Y., Dan, L., Lei, F., Nancai, Y., and Wen, S. Baicalin suppresses expression of Chlamydia protease-like activity factor in Hep-2 cells infected by Chlamydia trachomatis. Intern Med 2001;40:764-8. Bonham, M., Posakony, J., Coleman, I., Montgomery, B., Simon, J., and Nelson, P. S. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Food Chem Toxicol. B., Ro, J. Y., and Woo, S. S. Antiallergic herbal composition from Scutellaria baicalensis and Phyllostachys edulis. Total flavonoids induced increases in DNA fragmentation and mitochondrial pathway apoptosis(30). Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors. View abstract. View abstract. View abstract. J Nat Prod 2009;72(9):1616-1619. It might cause drowsiness. Alcohol: Alcohol interacts with Baicalin and can cause some serious Skullcap side effects like drowsiness, dizziness, and sleepiness. Ann Palliat Med. Journal of Chinese medicinal materials 2002;25(6):451-453. Taking Baikal skullcap might decrease how well the body gets rid of lithium. Associations between prescribed Chinese herbal medicine and risk of hepatocellular carcinoma in patients with chronic hepatitis B: a nationwide population-based cohort study. Protective effect of scutellaria baicalensis stem-leaf total flavonoid against hippocampus neurodamage induced by injection A25-35. Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others. Morgan SL, Baggott JE, Moreland L, et al. View abstract. View abstract. Lee, S. W., Song, G. S., Kwon, C. H., and Kim, Y. K. Beneficial effect of flavonoid baicalein in cisplatin-induced cell death of human glioma cells. Int J Antimicrob.Agents 2009;34(3):284-285. However, there are concerns that this combination product might cause liver problems in some people. View abstract. Baikal skullcap might have an effect like a water pill or "diuretic." Chinese journal of modern developments in traditional medicine 1990;10(5):278-9. S. barbata also prevented liver injury by attenuating NF-kB-mediated inflammation and oxidative stress(31)and increasing superoxide dismutase levels(16). WebMD does not provide medical advice, diagnosis or treatment. Journal of Chinese medicinal materials 2002;25(6):451-453. View abstract. View abstract. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. Planta Med 2010;76(7):678-682. Li WJ, Bao J, Zheng DC, et al. Eksp Klin Farmakol 1997;60:49-51. In vitro studies suggest that S. barbata has antibacterial(1), antioxidant(15), antimutagenic(2), and anticancer(3)(4)(5)(6)(7)(8)(10)(11)(12) properties. Scheck, A. C., Perry, K., Hank, N. C., and Clark, W. D. Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells. Treatment of acute bronchiolitis with Chinese herbs. Ceska.Slov.Farm. Chen, C. S., Chen, N. J., Lin, L. W., Hsieh, C. C., Chen, G. W., and Hsieh, M. T. Effects of Scutellariae Radix on gene expression in HEK 293 cells using cDNA microarray. Cancer Treat Rev 2009;35(1):57-68. J Nat Prod 1998;61:1413-5. Tan, H., Tang, Y., Zhou, X., Xiao, X., and Li, J. View abstract. Kim M, Lee BC. View abstract. View abstract. Lee, E., Enomoto, R., Suzuki, C., Ohno, M., Ohashi, T., Miyauchi, A., Tanimoto, E., Maeda, K., Hirano, H., Yokoi, T., and Sugahara, C. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. Dosage: 39 g/day/adult. Scutellaria Baicalensis ( Baical Skullcap ) is a plant. Antitumor activity of chloroform fraction of, In vitro anti-leukemic activity of the ethno-pharmacological plant. Levy RM, Khokhlov A, Kopenkin S, et al. Chen et C. Ling and Scutellaria baicalensis Georgi. J Nat Prod 2009;72(9):1616-1619. 5. View abstract. 2-25-2009;122(1):20-27. Cancer Lett. View abstract. 5-17-2011;135(2):359-368. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. View abstract. Ciesielska, E., Wolszczak, M., Gulanowski, B., Szulawska, A., Kochman, A., and Metodiewa, D. In vitro antileukemic, antioxidant and prooxidant activities of Antoksyd S (C/E/XXI): a comparison with baicalin and baicalein. Regulatory effects of gibberellic acid (GA3) on shoot and root formation of Huang-qin (Scutellaria baicalensis) in vitro. Ethnopharmacological and bioactivity guided investigation of five TCM anticancer herbs. J Ethnopharmacol. Am J Physiol Endocrinol Metab. No matter new buyer or old purchaser, We believe in long expression and trusted relationship for Scutellaria Baicalensis Root, Nootropics Modafinil, Herbal Extract Oil, Maca Extract Liquid, Hawthorn Extract Vs Hawthorn Berry. Keep in mind that natural products are not always necessarily safe and dosages can be important. Ye F, Wang H, Jiang S, et al. Leuk.Res 2007;31(4):523-530. Lin, C. C., Kuo, C. L., Lee, M. H., Lai, K. C., Lin, J. P., Yang, J. S., Yu, C. S., Lu, C. C., Chiang, J. H., Chueh, F. S., and Chung, J. G. Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. View abstract. Onco Targets Ther 2016;9:2935-43. Regulska-Ilow, B., Biernat, J., Grajeta, H., Ilow, R., and Drzewicka, M. Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. View abstract. Details. View abstract. View abstract. Int J Cancer 9-10-2003;106(4):559-565. This could change the effects and side effects of these medications. Chang, Y. L., Shen, J. J., Wung, B. S., Cheng, J. J., and Wang, D. L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. First-aid measures Inhalation Move to fresh air. Inhibitory effects of flavonoids from Scutellaria baicalensis on Epstein-Barr virus activation and their anti-tumor-promoting activities. 2004;50(3):279-285. Pharmacology 2006;77(2):71-77. People with diabetes should not take Chinese skullcap without consulting a doctor as it may lower blood sugar, View abstract. Scutellaria baicalensis is an herb used in traditional Chinese medicine to treat a variety of conditions including hepatitis, infections, and cancer. Chen C, Mireles RJ, Campbell SD, et al. View abstract. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. This will help them manage your care and keep you safe. Gao, J., Morgan, W. A., Sanchez-Medina, A., and Corcoran, O. Accessed on September 1, 2021. Reichenbach S, Juni P. Medical food and food supplements: not always as safe as generally assumed. African Journal of Biotechnology 2011;10(26):5182-5192. Baikal skullcap might cause sleepiness and slowed breathing. Ding, X. F., Gao, H. N., Guo, X. H., Wang, Z. View abstract. Arch Dis Child 1993;68:468-71. Zhong.Yao Cai. View abstract. In some cases, this might change the effects and side effects of a medication. A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. Bleeding disorders. View abstract. Some of the supplements and medicines containing Scutellaria baicalensis herb have been shown to reduce the symptoms of arthritis and joint pain. At this time there is not enough scientific information to determine an appropriate range of doses for Baikal skullcap. Zhongguo Zhong.Yao Za Zhi 2008;33(9):1064-1066. Yao Xue.Xue.Bao. Baikal skullcap might slow blood clotting. J Cell Biochem 10-1-2010;111(2):274-283. Jiang, R. H., Su, W. C., Liu, H. F., Huang, H. S., and Chao, J. I. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. 2010;48(5):1202-1209. Zhongguo Ying.Yong.Sheng Li Xue.Za Zhi 2009;25(3):344-348. vitamins, herbs, dietary supplements a-z list. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. Hou, Y. C., Lin, S. P., Tsai, S. Y., Ko, M. H., Chang, Y. C., and Chao, P. D. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. An herbal supplement containing S. baicalensis reduced symptoms of osteoarthritis(22). Most studies have been done in the lab rather than in humans, and suggest anti-inflammatory and antioxidant activity. Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others. Baikal skullcap might lower blood sugar levels. View abstract. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. Shin NR, Gu N, Choi HS, Kim H. Combined effects of Scutellaria baicalensis with metformin on glucose tolerance of patients with type 2 diabetes via gut microbiota modulation. View abstract. Cancer Chemother.Pharmacol 2011;67(5):1063-1072. Shurygin, A. Y., Bezzubov, N. V., Ignatova, E. A., Nikolaev, S. M., and Viktorov, I. V. Baikal skullcap extract stimulates neurite growth in cultures of rat dorsal root Ganglia. Pharmacist's View abstract. It is not an approved drug. View abstract. Mol Pharmacol 2001;60(3):507-513. Alcohol: Alcohol interacts with Baicalin and can cause some serious Skullcap side effects like drowsiness, dizziness, and sleepiness. J Altern Complement Med 2002;8(5):567-572. Chalasani N, Vuppalanchi R, Navarro V, et al. [The effect of an extract of Baikal skullcap (Scutelleria baicalensis) on succinic acid oxidation by the brain mitochondria in rats with hypoxia]. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee. 1-27-2011;133(2):634-641. Case ReportsAcute liver injury: In patients with arthritis, following consumption of formulas containing baicalin derived from S. baicalensis or Chinese skullcap(18)(24). View abstract. Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. View abstract. J Biomed.Sci 2009;16:27. View abstract. Baikal skullcap is used to treat respiratory infections, hay fever, and fever. Braude MR, Bassily R. Drug-induced liver injury secondary to Scutellaria baicalensis (Chinese skullcap). View abstract. Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. Planta Med 2000;66:91-3. The compound baicalein exhibited only inhibitory effects(9). All rights reserved. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. J Ethnopharmacol. View abstract. Eur J Drug Metab Pharmacokinet. Zhu, G., Li, C., and Cao, Z. Inhibitory effect of flavonoid baicalin on degranulation of human polymorphonuclear leukocytes induced by interleukin-8: potential role in periodontal diseases. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional Chinese medicine to treat conditions of inflammation, hypertension, cardiovascular diseases, etc. Chromatographic fingerprint and quantitative analysis of seven bioactive compounds of, Inhibition of Tumor Growth and Immunomodulatory Effects of Flavonoids and Scutebarbatines of, Using the gene expression signature of scutebarbalactone VN isolated from. View abstract. Huang, W. M., Yan, J., and Xu, J. View abstract. If combined with such drugs, it can have potential side effects, as resulted in a laboratory test. In some cases, this might change the effects and side effects of a medication. Burnett BP, Jia Q, Zhao Y, Levy RM. Cell Mol Biol Res 1993;39(2):119-124. View abstract. View abstract. Letter/Prescriber's Letter. Baumann, S., Fas, S. C., Giaisi, M., Muller, W. W., Merling, A., Gulow, K., Edler, L., Krammer, P. H., and Li-Weber, M. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. PL-Detail Document, Liver Toxicity and Limbrel. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel 2009;29(2):519-521. Chang, W. H., Chen, C. H., and Lu, F. J. A traditional Chinese herbal medicine loaded with potent antioxidant and anti-inflammatoryflavonoids such as baicalin, baicalein, and wogonin. View abstract. In theory, Baikal skullcap might lower blood pressure too much in people prone to low blood pressure. J Med Food 2009;12:1143-8. In vitro, the flavonoid baicalin exhibits anti-inflammatory, antioxidant, and gram-positive antibacterial activity(3). Dosage: 39 g/day/adult. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Bacteriostatic activity of combined application of Galla chinensis, Scutellaria baicalensis and Rhizoma coptidis against MRSA in vitro. WebChinese skullcap, Scutellaria Baicalensis, also known as (Baikal) Baical Skullcap, is a herb that belongs to the Lamiaceae mint family. View abstract. Takeshita K, Saisho Y, Kitamura K, et al. WebScutellaria Baicalensis Root - China Manufacturers, Factory, Suppliers. Shih, H. C., Hsu, C. S., and Yang, L. L. In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. 2019;235:481-488. Yimam, M., Zhao, Y., Ma, W., Jia, Q., Do, S. G., and Shin, J. H. 90-day oral toxicity study of UP446, a combination of defined extracts of Scutellaria baicalensis and Acacia catechu, in rats. Lixuan, Z., Jingcheng, D., Wenqin, Y., Jianhua, H., Baojun, L., and Xiaotao, F. Baicalin attenuates inflammation by inhibiting NF-kappaB activation in cigarette smoke induced inflammatory models. View abstract. Chinese Journal of Gerontology 2010;30(7):926-928. Huang, Y., Tsang, S. Y., Yao, X., and Chen, Z. Y. View abstract. Ceska.Slov.Farm. Some medications are changed and broken down by the liver. There is concern that it might cause extra bleeding during and after surgery. Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. View abstract. 4-12-2011;134(3):884-891. You may ask and answer a query. Waisundara, V. Y., Hsu, A., Huang, D., and Tan, B. K. Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats. It's famous for containing anti-inflammatory natural salicylates (this powder, for example, is standardized to contain 53-65%), a close chemical relative to famous exfoliant salicylic acid.. A preliminary study of S. baicalensis along with metformin appeared to improved glucose tolerance, inflammation, and gut microbiota in patients with type 2 diabetes(23). View abstract. 1995;15(8):465-467. J Med Chem 10-21-2004;47(22):5555-5566. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. Protective effect of baicalein extracted from Scutellaria baicalensis against lipopolysaccharide-induced glomerulonephritis in mice. Tarrago, T., Kichik, N., Claasen, B., Prades, R., Teixido, M., and Giralt, E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Talk with your healthcare provider before using this product if you are taking lithium. J Ethnopharmacol. Baikal skullcap is also sometimes applied to the skin for psoriasis. Eur J Haematol. Jin BR, Chung KS, Kim HJ, An HJ. Contact Dermatitis. Intern Med 2001;40:764-8. The extract coming from the bark of the White Willow, a big (25 m/80 ft.) tree that likes to live on riverbanks. View abstract. Nutr Res 2009;29:298-304. In addition, it can reduce inflammation in the body can easily heal liver toxicity, and can detoxify the body. Food Chem . Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., and Chang, F. C. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. View abstract. 1. Phytother.Res 2007;21(12):1187-1192. Seattle, WA: Eastland Press 1996:107-8. View abstract. Curr Drug Targets.Cardiovasc.Haematol.Disord 2005;5(2):177-184. View abstract. View abstract. Scientific and clinical relevance to the fact is not determined, but it is better to stay on the safer side. View abstract. Journal of Dietary Supplements 2010;7:253. View abstract. Chang, W. H., Chen, C. H., and Lu, F. J. Cancer Lett. Nat Prod 2009 ; 34 ( 2 ):119-124 a ] pyrene and..., it can have potential side effects like drowsiness, dizziness, and,... Prostatic hyperplasia in rats gibberellic acid ( GA3 ) on shoot and root formation of Huang-qin Scutellaria! Skullcap ( Scutellaria baicalensis ) in vitro and in vivo 2004 ; 18 4! And Phyllostachys edulis J. and Dusek, J., and Lu, F. L., Chen, Y. Lines by a flavonoid, baicalin reduced airway injury and restored mitochondrial function ( )... And benzo [ a ] pyrene 7,8-dihydrodiol and benzo [ a ] pyrene 7,8-dihydrodiol and benzo [ a ] 7,8-dihydrodiol-9,10-epoxide! And Blaszczyk, J, Mireles RJ, Campbell SD, et al exhibited only effects... Exhibits anti-inflammatory, antioxidant, and can detoxify the body gets rid of lithium and Phyllostachys.! X., Xiao, X. F., Gao H, Jiang S, et al whether co-administration of garlic negative! 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